Advanced maternal age alters expression of maternal effect genes that are essential for human oocyte quality
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چکیده
منابع مشابه
Female Aging Alters Expression of Human Cumulus Cells Genes that Are Essential for Oocyte Quality
Impact of female aging is an important issue in human reproduction. There was a need for an extensive analysis of age impact on transcriptome profile of cumulus cells (CCs) to link oocyte quality and developmental potential with patient's age. CCs from patients of three age groups were analyzed individually using microarrays. RT-qPCR validation was performed on independent CC cohorts. We focuse...
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The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age-associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that specific depletion of Sirt2 disrupts maturational progression and spindle/chromosome organization in mouse oocytes, with compromised kinetochore-microtubule at...
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Maternal diabetes is known to cause neural tube defects (NTDs) in embryos and neuropsychological deficits in infants. Several metabolic pathways and a plethora of genes have been identified to be deregulated in developing brain of embryos by maternal diabetes, although the exact mechanism remains unknown. Recently, miRNAs have been shown to regulate genes involved in brain development and matur...
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background: due to increase in pregnancy complications in advanced age, this study was conducted to assess the relationship between advanced maternal age and the pregnancy complications. methods: pregnant women who admitted to the motazedi hospital in kermanshah were included in this analytic–cross sectional study. the study group was 1178 cases that divided into two sub-groups; 35-40 year-old ...
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Some studies indicate that children born to younger mothers are at a higher risk of wheezing and asthma. To investigate the maternal age associated with asthma in children, a case-control study on 310 asthmatic and 310 non-asthmatic children aged 3 to 4 years was organized during a one-year period. A questionnaire was used to obtain information about the child’s personal susceptibility factor...
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ژورنال
عنوان ژورنال: Aging
سال: 2020
ISSN: 1945-4589
DOI: 10.18632/aging.102864